Serum Immunoglobulin A Cross-Strain Blockade of Human Noroviruses

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Serum Immunoglobulin A Cross-Strain Blockade of Human Noroviruses

Background.  Human noroviruses are the leading cause of acute viral gastroenteritis, justifying vaccine development despite a limited understanding of strain immunity. After genogroup I (GI).1 norovirus infection and immunization, blockade antibody titers to multiple virus-like particles (VLPs) increase, suggesting that GI cross-protection may occur. Methods.  Immunoglobulin (Ig)A was purified ...

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ژورنال

عنوان ژورنال: Open Forum Infectious Diseases

سال: 2015

ISSN: 2328-8957

DOI: 10.1093/ofid/ofv084